This book focuses on the high school chemistry discipline, based on core literacy, and provides extremely effective and reasonable suggestions and methods on how to better cultivate students' chemical literacy and improve the overall teaching quality. Firstly, this work briefly introduces the relevant content of core literacy and students' all-round development, as well as core literacy and core literacy of the chemistry discipline. Secondly, based on core literacy, it explores the high school chemistry activity sheet guided learning mode, the improvement of teachers' teaching design ability, the "teaching, learning and assessment" integrated teaching, and the teaching mode integrating scenarios and micro-lessons. Then, it focuses on the "evidence reasoning and model cognition" literacy and carefully studies the teaching implementation strategies by taking "ionic reactions and equilibrium in aqueous solutions" as an example. Finally, it studies the design and practice of high school chemistry large unit assignments based on the core literacy of the chemistry discipline. This book has great promoting significance for the orderly advancement of high school chemistry teaching reform and the cultivation of high school students' core literacy in chemistry.