College students are the future of the motherland and the hope of the nation. Whether ideological and political education in colleges and universities can succeed will directly affect the healthy growth of college student talents and the success or failure of the cause of building socialism with Chinese characteristics. Based on this, this book takes ideological and political education in colleges and universities as the research object, and studies through methods such as questionnaire surveys and literature research how college teachers can promote the integration of multiculturalism and ideological and political education in colleges and universities, and how to carry out precise teaching based on big data in line with the requirements of the digital transformation and development of education, in order to further promote the reform and development of ideological and political education in colleges and universities in China. Exploring the reform and practice of ideological and political education in colleges and universities under the background of "cultural integration and the development of the times" in the new era can not only transform the traditional teaching concepts of college teachers and enrich teaching content, but also comprehensively improve the comprehensive quality of students, which is conducive to cultivating students into high-quality talents with both virtue and art in the new era.