This study proposes comprehensive and efficient talent cultivation strategies for the bottlenecks in the development of China's cross-border e-commerce industry. By deeply analyzing the current situation of talent cultivation for cross-border e-commerce in higher vocational education, this study identifies existing problems and challenges, and constructs a diversified teaching model, including project-based teaching, blended teaching, and the PAD class teaching model based on the Duifenyi platform. The aim is to enhance teaching effectiveness and students' practical abilities. The research also focuses on exploring the talent cultivation practice of cross-border e-commerce industry colleges from the perspective of industry-education integration, and proposes a new path of "industry-education integration and school-enterprise cooperation" to deliver high-quality and composite professionals for the cross-border e-commerce industry. This study not only enriches the theoretical system of cross-border e-commerce talent cultivation but also holds positive significance for promoting the sustainable development of China's cross-border e-commerce industry.